|Awarded On||August 19, 2020|
|Title||Interrogating the Senescence-Associated Secretory Phenotype and its Dependence On the ATM Protein Kinase|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas at Austin|
|Principal Investigator/Program Director||Tanya Paull|
|Cancer Sites||All Sites|
Chemotherapy and radiation are still standard therapies for many cancers and can be very effective in some contexts to block cancer cell growth. These types of acute treatments generate massive DNA damage in exposed tissues which causes cell death and also generates senescence - a state of permanent arrest. Unfortunately, senesence does not just block cancer cell growth but can also induce reprogramming of cellular signaling and metabolism, called the senescence-associated secretory pathway (SASP), that induces inflammation in surrounding tissues. This inflammatory response actually stimulates the growth of neighboring cells and has been shown to promote secondary tumor progression in some m...