|Awarded On||February 19, 2020|
|Title||Development of a Novel Strategy for Tumor Delivery of MHC-I-Compatible Peptides for Cancer Immunotherapy|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Zhen Fan|
*Pending contract negotiation
The use of vaccines to eliminate infectious diseases is one of the greatest achievements in human history; however, the dream of using vaccines to prevent or treat human cancer remains largely unfulfilled. The overall goal of this project is to explore a new therapeutic strategy to fulfill this dream by altering cancer cells so they can be recognized and destroyed by the immune system. We will develop a new technology to deliver infectious virus-related peptides specifically to targeted tumors. This will trick the human immune system to recognize cancer cells as infectious virus-infected cells and launch an immune response against them by reawakening immune cells developed through previous n...