Grant ID RP200271
Awarded On February 19, 2020
Title Development of a Novel Strategy for Tumor Delivery of MHC-I-Compatible Peptides for Cancer Immunotherapy
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Zhen Fan
Cancer Sites Breast
Contracted Amount $900,000*

*Pending contract negotiation

Lay Summary

The use of vaccines to eliminate infectious diseases is one of the greatest achievements in human history; however, the dream of using vaccines to prevent or treat human cancer remains largely unfulfilled. The overall goal of this project is to explore a new therapeutic strategy to fulfill this dream by altering cancer cells so they can be recognized and destroyed by the immune system. We will develop a new technology to deliver infectious virus-related peptides specifically to targeted tumors. This will trick the human immune system to recognize cancer cells as infectious virus-infected cells and launch an immune response against them by reawakening immune cells developed through previous n...

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