Grant ID RP200356
Awarded On February 19, 2020
Title Circulating Tumor DNA- Defined Minimal Residual Disease in Colorectal Cancer
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Clinical Translation
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Arvind Dasari
Cancer Sites Colorectal
Contracted Amount $2,399,998*

*Pending contract negotiation

Lay Summary

Circulating tumor DNA (ctDNA) are tiny fragments of DNA shed by cancer cells that can be detected in the blood of cancer patients. Detection of ctDNA after completion of all curative intent therapies in the absence of any cancer on scans (i.e. minimal residual disease, MRD) is associated with a very high risk of recurrence. Thus, ctDNA is a very good marker for stratifying risk of recurrence and holds great promise in radically changing our approach to taking care of CRC patients. However, since only small amounts ctDNA are present after surgery, more sensitive assays for MRD are needed. Furthermore, whether patients whose ctDNA disappears with chemotherapy have improved survival is unknown...

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