|Awarded On||February 19, 2020|
|Title||Heterogeneity of Enhancer Patterns in Colorectal Cancers- Mechanisms and Therapy|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Kunal Rai|
*Pending contract negotiation
Genetic and epigenetic events together establish pro-tumorigenic expression changes that drive a variety of cellular phenotypes observed in this disease. Based on transcriptomic signatures, colorectal cancer patients can be divided into 4 CMS (Consensus Molecular Subtypes) groups that are typified by activation of specific signaling pathways and oncogenic pathways. We have limited understanding of functional contribution of major epigenomic regulatory processes in driving these molecular and cellular phenotypes associated with colorectal cancers. Our preliminary results the heterogeneity of enhancer gains between different patients and identified 4 subgroups of patients based on their speci...