|Awarded On||February 19, 2020|
|Title||Adipocyte-Producing Noncoding RNA Promotes Liver Cancer Immunoresistance|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Liuqing Yang|
|Cancer Sites||Gallbladder, Liver and Intrahepatic Bile Duct|
*Pending contract negotiation
Obesity has been established as a risk factor in the development of a multitude of cancer types and causes substantial impairment of anti-tumor immunity. However, the underlying molecule mechanisms remain elusive. Our preliminary data demonstrated that a small nucleolar RNA (snoRNA),SNORD46,is upregulated in liver cancer and negatively correlates with the cytotoxic leukocytes infiltration. Genetic evidence indicated that the expression of SNORD46 leads to obesity and liver tumors resistant to immunotherapy. The goal of this proposal is to comprehensively characterize and implicate SNORD46 as a driver of obesity-associated liver cancer and demonstrate that targeting snoRNAs effectively improv...