|Awarded On||August 19, 2020|
|Title||Genome-Wide DNA Methylation Markers for Predicting the Risk of Liver Cancer in Non- Alcoholic Fatty Livers|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas A&M University System Health Science Center|
|Principal Investigator/Program Director||Robert Tsai|
|Cancer Sites||Gallbladder, Liver and Intrahepatic Bile Duct|
The Mexican American population in south Texas exhibits a disproportionately high number of liver cancer due to a high prevalence of non-alcoholic fatty liver disease (NAFLD), which affects 1 in 5 adults in Texas and 1 in 3 of its Hispanic population. The existence of a large population in Texas at risk for liver cancer provides an opportunity to develop and implement risk mitigation and disease prevention strategies that will have a major impact on the health of Texans. There is a large unmet need for tools that can be used to determine the risk of NAFLD individuals in developing cancer. Our objective is to identify DNA modification (called 'methylation') markers that can predict the develo...