|Awarded On||August 19, 2020|
|Title||Pathological Role of Neuronal Cell Cycle Re-entry in the Development of Chemotherapy- induced Peripheral Neuropathy|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas at San Antonio|
|Principal Investigator/Program Director||Hyoung-gon Lee|
|Cancer Sites||All Sites|
Chemotherapy-induced peripheral neuropathy (CIPN) is a devastating consequence of cancer treatment regimens that include neurotoxic chemotherapeutic agents such as cisplatin. CIPN is one of the most common, serious side effects that can lead to dose reductions or early discontinuation of chemotherapy, reducing the efficacy of cancer treatments and significantly impacts the quality of life of the patients due to debilitating neurological symptoms such as pain, tingling sensation, numbness and weakness. Despite the high prevalence and severity of CIPN, currently there is no effective treatment to prevent or reverse CIPN mainly due to the limited understanding of the pathogenic mechanism of CIP...