|Awarded On||August 19, 2020|
|Title||Targeting Fatty Acid Synthesis in NAFLD Related HCC|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Bingning Dong|
|Cancer Sites||Gallbladder, Liver and Intrahepatic Bile Duct|
The number of liver cancer has more than tripled in the past 20 years in the United States. Texas has the highest death rate from HCC in the nation. Patients' survival rate is very low due to very limited treatment methods. At the same time, the rate of obesity, and its related metabolic disease, such as fatty liver, is also increasing. These are major modifiable risk factors for HCC development. In Texas, the obesity rate is currently 33%, with 30% of the population having fatty liver disease. Thus, discovering novel HCC drug treatments for obesity/fatty liver related condition is of high priority in Texas. Nuclear receptor CAR has been found to promote liver cancer development in mice. Th...