Grant ID RP210127
Awarded On August 18, 2021
Title Engineered enteric nerve-perineural invasion models to improve predictive preclinical screens in early stage colorectal adenocarcinoma
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Texas A&M University
Principal Investigator/Program Director Shreya Raghavan
Cancer Sites Colorectal, Gallbladder, Liver and Intrahepatic Bile Duct, Pancreas
Contracted Amount $250,000*

*Pending contract negotiation

Lay Summary

Colorectal tumors actively recruit intrinsic enteric nerves (ENS) of the colon. They use the nerves as conduits by a process called perineural invasion (PNI) to promote their malignant growth and insidious spread. Nerves play a central role in tumors, because they can control several functions of tumors, including how fast they grow and how well they respond to cancer therapy. Very little is known about how nerves of the ENS change tumor function in CRC, because we currently simply do not have the capability to isolate and study the interactions of these two systems in the lab. We believe that we can reverse-engineer this tumor-nerve interaction by building an ENS-PNI platform. We will build...

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