|Awarded On||August 18, 2021|
|Title||Engineered enteric nerve-perineural invasion models to improve predictive preclinical screens in early stage colorectal adenocarcinoma|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas A&M University|
|Principal Investigator/Program Director||Shreya Raghavan|
|Cancer Sites||Colorectal, Gallbladder, Liver and Intrahepatic Bile Duct, Pancreas|
*Pending contract negotiation
Colorectal tumors actively recruit intrinsic enteric nerves (ENS) of the colon. They use the nerves as conduits by a process called perineural invasion (PNI) to promote their malignant growth and insidious spread. Nerves play a central role in tumors, because they can control several functions of tumors, including how fast they grow and how well they respond to cancer therapy. Very little is known about how nerves of the ENS change tumor function in CRC, because we currently simply do not have the capability to isolate and study the interactions of these two systems in the lab. We believe that we can reverse-engineer this tumor-nerve interaction by building an ENS-PNI platform. We will build...