|Awarded On||August 18, 2021|
|Title||Treating Metastatic Cancer using Microbubble-assisted Ultrasound-guided Immunotherapy of Cancer of Cancer (MUSIC)|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Jacques Lux|
|Cancer Sites||All Sites|
*Pending contract negotiation
Despite advances in the treatment of locally advanced cancers, patients with metastatic cancer often develop treatment resistance and succumb to the disease. Therefore, identifying new and effective treatment options for metastatic cancer is a major challenge and unmet clinical need. Cancer immunotherapy that targets the adaptive immune system such as immune checkpoint blockers has recently emerged as a revolutionary treatment for metastatic cancers. However, only a small subpopulation of patients benefits from immune checkpoint inhibitor treatment. There is now a realization that to improve the response rate of cancer patients to immunotherapy, stimulation of the innate immune system is al...