|Awarded On||February 16, 2022|
|Title||Dissect and disable altered tryptophan metabolism in MYC-driven tumors|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Maralice Conacci-Sorrell|
|Cancer Sites||Gallbladder, Liver and Intrahepatic Bile Duct|
Liver cancer is the third leading cause of cancer mortality worldwide. Excessive alcohol consumption, viral hepatitis, metabolic syndrome, and obesity are major causes of liver damage. Liver damage can progress to fatty liver disease, fibrosis, and cirrhosis, which dramatically increase the risk of cancer. Likely due to these environmental factors, the incidence of liver cancer in the United States has tripled in the last decades; however, the overall survival rates of patients with liver cancer have remained low.
Our work focuses on a simple question: What do cancer cells need to grow? To answer this question, we are focused on identifying the specific nutritional needs of cancer cells tha...