|Awarded On||February 16, 2022|
|Title||Structures and targeting of membrane-bound RAS signalsomes in cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Kenneth Westover|
|Cancer Sites||Leukemia, Skin|
Mutations in KRAS, HRAS, and NRAS are common drivers of lethal cancers. RAS must be anchored to the inside of cell membranes to work. This attachment to the membrane allows RAS proteins to organize into complexes. Raf kinases and other signaling proteins add to RAS complexes to form larger complexes that efficiently signal to regulate important cellular processes.
The structures of these complexes are poorly understood and hard to study because they are short-lived. The Westover lab has published evidence, including biological validation, for two structural models of RAS complexes, including a symmetric RAS model and an asymmetric model. We believe these structures have unique functions in c...