|Awarded On||February 16, 2022|
|Title||ROLE OF GERMLINE BRCA PATHWAY MUTATIONS IN DEVELOPMENT OF PEDIATRIC CANCERS|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Sharon E Plon|
Although pediatric cancer remains relatively rare, it is the leading cause of death by disease in children past infancy. Recent studies have shown that ~10% of all children with solid tumors (in the brain or other organs) are born with a mutation in a known cancer predisposition gene, demonstrating that there is significant genetic component to cancer in children.
The Plon lab seeks to better define the genetic predisposition to childhood cancer. One recent study from our lab surveyed 615 children with rhabdomyosarcoma (RMS), a cancer that forms in muscles, to learn how often these patients were born with a mutation in cancer genes. Surprisingly, we found six patients with mutations in th...