|Awarded On||September 14, 2022|
|Title||Establish New Cryo-EM Core Services to Drive Cancer Research and Drug Discovery at UTSouthwestern Medical Center|
|Award Mechanism||Core Facility Support Awards|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Mike Rosen|
|Cancer Sites||All Sites|
Cancer initiation, progression and metastasis are caused by changes in protein machines that control core cellular processes. Cryo-electron microscopy (cryo-EM) is a powerful technology that can reveal three-dimensional pictures of these machines-the spatial arrangements of their atoms-explaining how they function normally and are defective in cancer. This information is essential to understanding the mechanisms that drive cancer, identifying drug targets, and developing therapeutics. Leveraging the current CPRIT grant, UTSW built the leading cryo-EM facility in the central United States. Since 2017 the facility has generated a huge body of cutting-edge research (69 publications) on some of ...