Grant ID RP230140
Awarded On February 15, 2023
Title Changes in Tumor Microenvironment that Promote Cachexia
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Rodney Infante
Cancer Sites Colorectal, Lung and Bronchus
Contracted Amount $1,050,000
Lay Summary

Cancer cachexia is a devastating wasting syndrome consisting of significant fat and muscle loss observed in 50% of all cancers. It is responsible for 1/3 of all cancer-related deaths. Cancer patients with cachexia live half as long as patients with the same cancers without cachexia. These emaciated patients have a poor quality of life which precludes them from receiving treatments for their respective cancer. Currently there are no effective treatments for this wasting syndrome, in part because of a lack of markers that could identify patients early in the wasting process. Therefore, clinicians often use non-approved medications for cancer cachexia with limited benefit. We therefore ...

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