|Awarded On||February 15, 2023|
|Title||Overcoming therapy resistance by integrated computational modeling of the bone metastatic niche in prostate and renal cancers|
|Award Mechanism||Individual Investigator Research Awards for Computational Biology|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Eleonora Dondossola|
|Cancer Sites||Bone, Kidney and Renal Pelvis, Prostate|
Bone metastases (BM) are a source of significant mortality for patients with advanced prostate and renal cancer, which is mainly caused by treatment failure. The interaction between cancer and bone cells has recently emerged as a key mediator of treatment resistance, but the lack of appropriate experimental systems prevents rigorously addressing its involvement. Mouse models of BM have identified key mechanisms of therapy response and are indispensable to investigating the pathophysiology of this challenging disease. However, they are limited in addressing the complexity of drug testing (e.g. number of combinations and observation time) in a time-cost effective manner. The integration of ce...