|Awarded On||February 15, 2023|
|Title||Characterization of 3D Genome Organization and Transcriptional Regulation in Prostate Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Ram S Mani|
Enhancers are DNA switches that regulate the expression of genes in cells. Alterations in enhancer activity is increasingly linked to cancer development. Prostate cancer (PCa) is the prototypical enhancer-driven cancer. It harbors recurrent genomic rearrangements and structural variations that promote the mis-regulation of transcription factor genes by enhancer hijacking. Enhancers can be located within or outside genes and can regulate multiple genes simultaneously. However, pairing enhancers with their target genes is extremely challenging. This is because enhancers can regulate genes that are located hundreds of kilobase pairs away and can often skip the nearest genes. Our group has creat...