|Awarded On||August 16, 2023|
|Title||The Role of Renal Lipotoxicity in Carcinogenesis|
|Award Mechanism||TREC: Pilot Study Award|
|Institution/Organization||Texas Tech University Health Sciences Center|
|Principal Investigator/Program Director||Ion Bobulescu|
|Cancer Sites||Kidney and Renal Pelvis|
*Pending contract negotiation
Clear cell renal cell carcinoma (ccRCC) is the most common and deadly subtype type of cancer affecting the kidney. People with obesity have a much higher risk of developing ccRCC than people without obesity, for reasons that are incompletely understood. We and others have shown that people with obesity accumulate excess fat in the kidney. Excess fat in other organs such as the liver and pancreas has been shown to contribute to cancer in those organs. However, whether excess fat in the kidney may contribute to kidney cancer has not been studied. One characteristic of ccRCC is accumulation of excess fat in cancer cells. This fat accumulation has traditionally been thought to occur after cancer...