|Awarded On||August 16, 2023|
|Title||Role of transcription factor UBTF in pancreatic cancer|
|Award Mechanism||TREC: Pilot Study Award|
|Institution/Organization||The University of Texas Rio Grande Valley|
|Principal Investigator/Program Director||Bilal Hafeez|
*Pending contract negotiation
Pancreatic cancer (PanCa) is a significant problem, and its treatment is a major challenge in front of onco-physicians. It shows only marginal survival benefits of 6 months with the available therapeutics. According to the American Cancer Society, PanCa is the third leading cause of cancer-related deaths in the United States. Thus, understanding the biology of PanCa is urgently required. Aberrant ribosome biogenesis is the hallmark of many cancers and has been associated with poor prognosis. Cancer cells show a significantly high demand for protein synthesis and to meet this demand they modify ribosomal machinery to produce onco-ribosomes. Through this project, we for the first time will inv...