Grant ID RR200025
Awarded On February 19, 2020
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization Rice University
Principal Investigator/Program Director Anna-Karin Gustavsson
Cancer Sites Colorectal, Lymphoma
Contracted Amount $2,000,000
Summary of Goals and Objectives

Cellular function is regulated by molecular spatial distributions, interactions, and dynamics, all of which are often perturbed during cancer progression and metastasis. To quantify molecular structures and the interplay between molecules requires accurate 3D imaging of single molecules at the nanoscale.

In this work I will fill three technological gaps and develop an innovative and versatile imaging platform for simultaneous multi-color 3D single-molecule super-resolution imaging and 3D chromosomal loci tracking with high spatiotemporal resolution throughout entire live cancer cells. I will then use my platform to deduce molecular mechanisms for improved understanding of cellular function, ...

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