| Grant ID | RR200063 |
| Awarded On | August 19, 2020 |
| Title | Recruitment of First-Time, Tenure-Track Faculty Members |
| Program | CPRIT Scholar |
| Award Mechanism | Recruitment of First-Time, Tenure-Track Faculty Members |
| Institution/Organization | Baylor College of Medicine |
| Principal Investigator/Program Director | Hongjie Li |
| Cancer Sites | Colorectal, Small Intestine |
| Contracted Amount | $2,000,000 |
| Summary of Goals and Objectives |
A central goal of my future research is to discover how aging triggers tumor onset in the regenerating intestine. Age-related epithelial tumorigenesis is a complex and dynamic process, consisting of three major stages: initiation, progression, and metastasis. Accumulating evidence suggests that tumor initiation is not only due to cell intrinsic changes, such as age-related accumulated oncogenic mutations, but also can be triggered by tissue microenvironment changes, such as chronic inflammation. I am interested in identifying the molecular mechanisms of age-related triggering of colorectal cancers by applying state-of-the-art in vivo cell-surface proteomics and single-cell transcriptomic an... |