|Awarded On||May 20, 2020|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Jason Lee|
|Cancer Sites||All Sites|
|Summary of Goals and Objectives||
The goal of my research is to understand how the endoplasmic reticulum (ER) and membrane-less mRNA-protein (RNP) granules contribute to metastasis and inflammation.
There are 3 significant moments in the life of a cancer cell. One is initiation, which is when a cell deviates from normal functions and transforms into a tumor-forming cancer cell. The second is metastasis, which is when a cancer cell switches once more to escape the tumor and seed new tumors. Lastly, tumor cells can alter pathways to obtain drug resistance.
I recently discovered that RNP granule disassembly is regulated by a novel interface between the ER and RNP granules. I am excited to study this interface in the context of ...