|Awarded On||August 19, 2020|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Andrew Sandstrom|
|Cancer Sites||All Sites|
|Summary of Goals and Objectives||
Inflammation is a critical immune response that acts to recruit inflammatory cells to sites of infection and initiate protective immune responses; however, chronic inflammation promotes oncogenesis and tumor growth. While the pathogen-associated triggers of inflammation are well characterized, the molecular mechanisms that trigger chronic inflammation in cancer remain unclear. To clarify mechanisms that induce cancer-associated inflammation, I will investigate how activation of the NLRP1 inflammasome contributes to inflammation in cancer.