|Awarded On||November 18, 2020|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Jeanine Van Nostrand|
|Cancer Sites||Gallbladder, Liver and Intrahepatic Bile Duct|
|Summary of Goals and Objectives||
Metabolic deregulation, largely associated with loss of the energy stress sensor AMPK, has become appreciated as a significant risk factor for hepatocellular carcinoma (HCC). HCC is a deadly cancer with very few effective treatments for the advance stages and is increasingly prevalent in Texas, in part due to a high rate of obesity and non-alcoholic fatty liver disease. The high incidence and mortality rates of patients with HCC emphasize the necessity for both understanding the etiology of HCC and developing preventative therapeutics against HCC.
While previous studies have uncovered a correlative role for AMPK activation in HCC, neither the functional role of AMPK in HCC prevention nor the...