|Awarded On||May 19, 2021|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Chen Yao|
|Cancer Sites||Kidney and Renal Pelvis|
|Summary of Goals and Objectives||
T cells become dysfunctional during cancer, a state termed T cell exhaustion, which limits tumor control by the immune system. Immune checkpoint inhibitors (ICI) are designed to reinvigorate antitumor T cell immunity, but only a fraction of cancer patients respond to these drugs. A newly discovered subset of CD8 T cells, known as stem-like CD8 T cells, mediates ICI-induced antitumor T cell immunity in mice and positively correlates with the ICI-induced response in cancer patients. Thus, enhancing the stem-like CD8 T cell response represents a potential strategy for improving the ICI efficacy.
Renal cell carcinoma (RCC), a prevale...