|Awarded On||May 19, 2021|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Joshua Riback|
|Cancer Sites||Breast, Leukemia|
|Summary of Goals and Objectives||
Biological condensates, such as the nucleolus and nuclear speckles, facilitate basic cellular functions including ribosome biogenesis and splicing that are often altered during tumorigenesis. The goal of my research is to determine a detailed mechanistic relationship between condensate form and function and how this changes during cellular differentiation and oncogenesis.
During my postdoctoral work, I determined that condensates in cells were composition-dependent, stabilized by heterotypic interactions between biomolecules and, in the case of the nucleolus, facilitated the efflux of assembled ribosomal subunits via an effective thermodynamic proof-reading. This suggests that changes in bio...