|Awarded On||May 19, 2021|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Courtney Schroeder|
|Cancer Sites||All Sites|
|Summary of Goals and Objectives||
Cytoskeletal proteins are conventionally thought to be conserved, yet evolutionary diversification in the form of gene-family expansions and accelerated amino-acid substitutions are unexpectedly found among actins and tubulins in mammals, including humans. Expression of divergent cytoskeletal proteins is restricted to the testis, but these genes are frequently mis-expressed in cancers. I identified six testis cytoskeletal proteins that appear to play prominent roles in cancer biology as: high expression is prognostic for low probability of survival; many of their encoding genes are mutated, amplified, or deleted in several c...