|Awarded On||August 18, 2021|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Shih-Han Lee|
|Summary of Goals and Objectives||
The long-term vision of my research is to reveal errors hiding in RNA and understand their pathophysiological impact on tumorigenesis. The goal of this proposal is to investigate the functional significance of aberrant RNA isoforms generated by alternative cleavage and polyadenylation (APA) occurring in 3' untranslated region (3'UTR), discover altered RNA isoforms generated by intronic polyadenylation (IPA, a class of APA), and decipher mechanisms underlying IPA formation in cancer.
Aim 1 is to understand how cancer-gained 3'UTRs regulate gene functions independent of protein sequence to foster cancer progression. I will evaluate how the 3'UTR dictates the interaction of specific substrates w...