Grant ID RR210085
Awarded On August 18, 2021
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Yuan Pan
Cancer Sites Brain and Other Nervous System
Contracted Amount $2,000,000
Summary of Goals and Objectives

My primary research interest is to understand the emerging role of neuronal activity in childhood cancer. Neurofibromatosis-1 (NF1) is a cancer predisposition syndrome; children born with mutations in the NF1 tumor suppressor gene are predisposed to nervous system neoplasms [e.g., optic pathway gliomas (OPG) and malignant peripheral nerve sheath tumors (MPNST)]. Using a mouse model of NF1-OPG, I uncovered, for the first time, that neuronal activity can drive the initiation of nervous system cancer (Pan et al., Nature, 2021). Moreover, I found that the cancer-predisposing Nf1 mutation synergizes with neuronal activity to initiate OPG.

At MD Anderson, my first objective will be to expand on my...

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