Grant ID RR220010
Awarded On November 18, 2021
Title Recruitment of Established Investigators
Program CPRIT Scholar
Award Mechanism Recruitment of Established Investigators
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director James Harbour
Cancer Sites Eye and Orbit
Contracted Amount $6,000,000
Summary of Goals and Objectives

The success of checkpoint inhibitors for treating metastatic cutaneous melanoma and other cancers has generated interest in immunologic therapies; however, only a subset of cancers responds to such therapies, whereas many cancers are unresponsive. While low tumor mutation burden may explain in part why cancer types are immunologically “cold,” recent discoveries suggest that active immune suppression by the tumor plays an important role. It is unclear in most cases how cancer cells create such an inhibitory immune microenvironment. Elucidating the mechanisms of this immunosuppression could generate novel therapies. One cancer ...

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