|Awarded On||November 18, 2021|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas at Dallas|
|Principal Investigator/Program Director||Filippo Romiti|
|Cancer Sites||Breast, Lung and Bronchus, Stomach|
|Summary of Goals and Objectives||
The principal aim of the proposed studies will be the bench-to-bedside development of polycyclic polyprenylated acylphloroglucinols (PPAPs) into a new class of anti-cancer drugs through comprehensive synthetic and biological investigations. We will develop a practical, efficient, and versatile strategy for enantioselective synthesis of significant quantities of PPAPs so that detailed biological and pharmacokinetic studies can be easily and reliably performed. Access to a library of PPAPs analogs and preparation of antibody-drug conjugates (ADCs) will facilitate the discovery of novel, highly potent, and uniquely selective anti-cancer drugs. Aim 1: Practical strategy for synthesis of PPAPs. T...