Grant ID RR220069
Awarded On May 18, 2022
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director William Hudson
Cancer Sites Brain and Other Nervous System, Breast, Lung and Bronchus
Contracted Amount $2,000,000
Summary of Goals and Objectives

CD8+ T cells are an important arm of the adaptive immune system with the capability to kill cells presenting non-self or mutated-self antigen through MHC I. In conditions of antigen persistence, such as cancer, CD8+ T cells differentiate into an “exhausted” state characterized by lack of cytotoxic capacity, diminished proliferative potential, and expression of co-inhibitory signaling molecules that further suppress T cell function. Antibodies that inhibit these co-inhibitory signaling pathways, such as PD-1 blocking antibodies, have been approved for the treatment of multiple cancer types. However, most cancer patients do not respond to existing immunotherapies, highlighting the need for add...

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