|Awarded On||August 17, 2022|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Steven Boeynaems|
|Cancer Sites||Brain and Other Nervous System, Lung and Bronchus|
|Summary of Goals and Objectives||
Cancer cells are exposed to myriad stresses in the tumor microenvironment, including starvation, hypoxia, acidification, chemotherapy, among other potential insults. Thus, cancer cells are under strong selective pressure to evolve stress tolerance mechanisms to prevent their proteostatic collapse. Such coping strategies are the Achilles’ heel of cancer, and constitute promising targets for therapeutic intervention. In previous work, I have identified so-called biomolecular condensates—membraneless assemblies of proteins and nucleic acids that form via phase separation—as key stress-responsive compartments that allow cells to sense and respond to the environment. Unsurprisingly, I also found ...