|Awarded On||August 16, 2023|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas at Dallas|
|Principal Investigator/Program Director||Chen Cao|
|Cancer Sites||All Sites|
|Summary of Goals and Objectives||
The interactions between cellular compositions of the tumor microenvironment (TME) are increasingly recognized as major determinants of tumor progression. Recently, the rapid development of single cell sequencing technologies has revolutionized our understanding of the biological characteristics and dynamics of the entire tumor ecosystem, such as mechanisms of intratumoral and intertumoral heterogeneity. However, current scRNASeq studies generating detailed catalogues of cell types and states work from the top down to study how cell components interact in TME, lacking access to tweak and quantify the contributions of different cell types in normal and malignant tissue organizations. To lever...