|Awarded On||August 16, 2023|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Simon Eschweiler|
|Cancer Sites||Lung and Bronchus, Ovary, Skin|
|Summary of Goals and Objectives||
Immunotherapies have become crucial treatment options for a variety of cancer types. However, fewer than 30% of people respond to a given therapy. Hence, as low efficacy and widespread immune-related toxicity severely limit both treatment efficacy and combination therapy options, there is urgent need to develop novel immunotherapy targets with an improved efficacy and safety profile. Thus, the overall goal of this application is to devise and test novel immunotherapeutic strategies through mechanism-guided approaches. Accordingly, the objectives of my proposal are to (i) assess the clinical validly of novel cellular targets of cancer immunotherapy, (ii) develop and/or test immunotherapies th...